![]() Increased plasma concentrations may cause increased side effects such as headache, fatigue, insomnia, and anxiety. Increased drug exposure without effects on peak concentration may cause increased adverse events or toxicity evidenced by renal toxicity, hepatic toxicity, and increased immunosuppression. ![]() 21 – 24įluvastatin (Lescol), pravastatin (Pravachol), rosuvastatin (Crestor)įibric acids, nicotinic acid, or bile acid sequestrantsĬyclosporine (Sandimmune, Neoral), tacrolimus (Prograf) Increased plasma concentration may cause headaches, gastrointestinal complaints, hepatic inflammation, and myopathies (e.g., rhabdomyolysis). 9Īmlodipine (Norvasc), diltiazem (Cardizem), verapamil (Calan)Ītorvastatin (Lipitor), lovastatin (Mevacor), simvastatin (Zocor) Increased plasma concentration may lead to flushing, peripheral edema, headaches, tachycardia, symptomatic hypotension, and myocardial infarction in rare cases. Don’t drink grapefruit juice if you’re taking any of these medications, unless advised to by your doctor: Some statins ( cholesterol-lowering drugs): lovastatin ( Mevacor ), atorvastatin. 9, 20įelodipine (Plendil), nicardipine (Cardene), nifedipine (Procardia), nimodipine (Nimotop), nisoldipine (Sular) Increased plasma concentration of quinidine and disopyramide may be cardiotoxic causing torsades de pointes. 19ĭigoxin (Lanoxin), diltiazem (Cardizem), verapamil (Calan) Some statins, including atorvastatin (Lipitor). Increased plasma concentrations of amiodarone may cause thyroid or pulmonary toxicity, liver injury, QTc prolongation, proarrhythmic disorders, and bradycardia. You should avoid large quantities of grapefruit or grapefruit juice, which can increase the risk of serious side effects. Additional drugs found to be affected by grapefruit juice include, but are not limited to. ![]() Amiodarone (Cordarone), disopyramide (Norpace), quinidine ![]()
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